Authors' conclusions: there is good evidence that topical mupirocin and topical fusidic acid are equally, or more, effective than oral treatment due to the lack of studies in people with extensive impetigo, it is unclear if oral antibiotics are superior to topical antibiotics in this group. Topical antibiotics compared with other topical antibiotics: o fusidic acid was more effective than neomycin/bacitracin (n = 24 o there is insufficient evidence as to whether oral antibiotics are better than topical antibiotics for more serious and extensive forms of impetigo84 to 20 o fusidic acid was significantly better than oral. The evidence identified in this report supports the clinical efficacy of topical antibiotics, specifically mupirocin and fusidic acid, for the treatment of impetigo insufficient evidence was identified to support the clinical efficacy of bacitracin and a lack of evidence was identified on other topical antibiotics of interest. The community pharmacist seeking to supply fusidic acid for impetigo must ensure that all patients have been screened and meet the use of topical fusidic acid 2% within the last 3 months known hypersensitivity to any component of the medicine.
Topical antimicrobials are better tolerated than oral medication, which may improve compliance, particularly in children 35 for acute superficial skin infections, the efficacy of topical fusidic acid or mupirocin has been shown to be at least comparable to oral treatment, other than in more severe cases of impetigo 36– 40 a small number of. In vitro activity of fusidic acid and mupirocin against coagulase-positive staphylococci from pets a loefﬂer1, treatment of staphylococcal skin infections such as impetigo, the mrsa and mrsp pet carriers14 topical use of fusidic acid in humans, at least long-term, has been associated with an increase. Fucidin cream with fusidic acid 2% is an antimicrobial antibiotic that was first used as a topical solution in the 1940s originally, fucidin was used to treat all kinds of bacterial skin infections, burn, and infections in wounds.
In nottingham the topical use of fusidic acid cream alone or in combination with topical steroids for impetigo and eczema has increased, but this has been associated with a rise in the rate of resistance to fusidic acid in s aureus isolates, particularly from cases of impetigo. Biomedical scientists are still contesting on whether the oral route or the topical route of treatment is more efficient, yet evidence-based practice indicates that topical ointments are as effective as oral treatment of impetigo (koning et al, 2002. Two of the most widely used topical treatments for impetigo at the time of review, fusidic acid and mupirocin, were identified as equally effective at reducing the severity of infection and time to recovery.
Topical antibiotic treatment for uncomplicated skin and skin structure infections: review of the literature and fusidic acid) efficacy with impetigo was this review found evidence for the. There is good evidence that topical mupirocin and topical fusidic acid are equally, or more, effective than oral treatment due to the lack of studies in people with extensive impetigo, it is unclear if oral antibiotics are superior to topical antibiotics in this group. A bpacnz article on management of impetigo recommended topical fusidic acid as initial treatment for children with small localised patches of impetigo nurse-led school clinics for the assessment and treatment of children with skin infections, eg the. Total text length is 9,067 characters (approximately 63 pages) excerpts from the paper the beginning: impetigo in young children: a case study a four-year-old female presented to the emergency department with an 8 day history of a rash around her mouth.
Fusidic acid 2% cream and sodium fusidate 2% ointment are topical antibiotic agents that are active against a wide range of bacteria that can be found in skin infections the trade name in new zealand is foban. These preparations are used to treat skin infections and more information fusidic acid is a steroid antibiotic that often topically in creams eyedrops but may the use of topical (skin eye. Topical application of fusidic acid is also effective against streptococci, corynebacteria, neisseria and certain clostridia 52 pharmacokinetic properties in vitro studies show that fusidic acid can penetrate intact human skin. Topical antibiotics such as mupirocin (bactroban) and fusidic acid (not available in the united states) are the preferred first-line therapy for impetigo involving limited body surface area a 4 , 8. Fusidic acid, a narrow-spectrum antibiotic, is used both systemically and topically to treat primary skin infections, including impetigo moreover, it has been used for a wide variety of less-common infections  , in the treatment of clostridium difficile colitis, and in staphylococcal infections in patients with cystic fibrosis.
Topical sodium fusidate (fusidic acid), currently not available in the united states, has been recognized as first-line therapy in europe and other parts of the world. We conclude that topical fusidic acid cream is an effective treatment for impetigo, with very few side effects, and can be considered a first choice in the treatment of impetigo in general practice the value of sole or adjunctive treatment with povidone-iodine can be questioned. Antibiotics, specifically mupirocin and fusidic acid, for the treatment of impetigo insufficient evidence was identified to support the clinical efficacy of bacitracin and a lack of evidence was identified on other topical antibiotics of interest.
Topical antibiotics other than mupirocin and fusidic acid can be considered inferior among the numerous β-lactamase resistant oral antibiotics studied in trials, none has been proved superior many of these studies were underpowered and designed to study a given treatment for several skin infections combined rather than to study impetigo. Treatment includes topical antibiotics such as mupirocin, retapamulin, and fusidic acid oral antibiotic therapy can be used for impetigo with large bullae or. Impetigo is a common infection of the skin it is contagious, which means it can be passed on by touching most cases occur in children but it can affect anybody of any age antibiotic cream usually clears the infection quickly the usual treatment of choice is topical fusidic acid alternatives are mupirocin cream or retapamulin cream if.